• Cancer itself – When cancer grows it damages the tissues. It causes inflammation, unusual stretching, irritation and all this can lead to pain. Like if we talk about a pancreatic cancer, when it grows or stretches it can irritate the diaphragm (main breathing muscle) and that cause shoulder pain
• Cancer spread – when cancer grows uncontrollably then it can spread to the nearby or distant body parts like the bone, liver, kidney, lymph nodes etc.
• Associated problems like bloating, constipation, blockage of ducts, clotting problems, distention of liver or abdomen etc.
• Cancer treatments like radiotherapy or chemotherapy are known to cause nerve pain (peripheral neuropathy. Surgery may also be associated with chronic persistent pain.
• Extra stress on other body parts – Often to protect one part of our body, we put pressure on other parts for example using crutches to offload a leg may become the source of shoulder pain as the crutches place extra load on my shoulder
• Other coincidental problems – it is not necessary that all pain that every cancer patient suffers is due to cancer. There could be other coincidental problems like in the general population such as arthritis. So it is important to identify not only the type of pain but also the source of pain, before we plan treatment.

Pain related to cancer may have different components such as background pain and breakthrough pain. These need to be taken into account while making treatment plans. Let’s take an example of pain due to pancreatic cancer. These patients may have a constant pain (background pain) and there may be increased pain that comes after eating (breakthrough pain). Breakthrough pain may happen due to provoked or unprovoked factors and when we make a treatment plan it is important to have a plan for breakthrough pain.

The post Why Does Cancer Cause Pain? appeared first on Dr Amod Blog.

What is peripheral neuropathy?

Peripheral nerves carry sensations from the different parts of your body to the brain and control the movement of our arms and legs. The set of symptoms resulting from damage to these nerves is addressed as Peripheral neuropathy. Symptoms are usually symmetrical starting from toes and fingers, and progress towards the body. Common symptoms include

• Tingling or pins and needles sensation in hands of feet
• Numbness and reduced ability to feel hot and cold
• Sharp, electric, burning pain
• Sensitivity to touch, pressure or temperature 
• Balance issues and difficulty walking
• Leg cramps 
• Weakness
• Difficulty with fine activities such as writing, buttoning and unbuttoning 

What is Chemotherapy Induced Peripheral Neuropathy (CIPN)?

Some of the chemotherapy drugs used to treat cancer can cause peripheral nerve damage. This is addressed as chemotherapy-induced peripheral neuropathy (CIPN).

The symptoms of CIPN include all peripheral neuropathy symptoms mentioned above, with the most common one being numbness and tingling starting in fingers and toes and progressing proximally as the condition progresses. This appears earlier and is generally more prominent than pain. CIPN can have an impact on ones sleep, mood, functionality and quality of life (QOL).

Symptoms can appear hours to days after chemotherapy and the condition can worsen with additional chemotherapy cycles. The progression usually levels off after stopping the chemotherapy except in the case of platinum-based drugs where the sensation may continue to deteriorate for several months.

Different patterns can be seen with different drugs like in Oxaliplatin (a chemotherapy drug) induced acute neuropathy, there is cold sensitivity, throat discomfort, discomfort swallowing cold liquids, and muscle cramps with more severe symptoms in upper limbs. The usually peaks 2 to 3 days after each dose and can increase in subsequent treatment cycles.

In Paclitaxel (another chemotherapy drug) induced acute neuropathy the pain occurs in truncal/hip distribution or lower extremities and tends to resolve more between doses. The symptoms peak approximately in 2 to 3 days after each dose and are not worsened in subsequent cycles.

What are my chances of getting CIPN?

CIPN affects approximately 30% and 40% of patients undergoing chemotherapy and the risk varies with factors such as

• Drugs used – Some drugs are more likely to cause CIPN than others. A list of some of these is included at the end of this blog.
• Duration of use
• Dose used
• Pre-existing neuropathy
• Comorbidities such as diabetes, vitamin deficiencies
• Age

Can CIPN be cured or is it permanent?

In most cases the CIPN symptoms go away with time. They can last for weeks, months, or even years after treatment. It does vary depending on the drugs, doses used and in some cases it can be permanent. Unfortunately, there is no clear cure or treatment that will repair nerve damage.

What should I do to deal with CIPN?

It is a good idea to report your symptoms to the team looking after you and they may consider altering the treatment plan to prevent your symptoms from worsening. This may involve dose delaying, reduction, stopping chemotherapy or substituting with other agents that do not cause CIPN. A pain specialist opinion should be taken if your symptoms are severe and require specialist input. A pain specialist may prescribe nerve types of painkillers which need to be taken regularly to help manage your symptoms.

Other measures which can help include

• Avoiding things that make your symptoms worse, such as hot or cold temperature, or tight clothes or shoes
• Regular exercises
• Avoiding smoking and alcohol
• Ensuring normal vitamin levels and blood sugars.

No medication or supplement has been shown to definitively prevent CIPN including N-acetylcysteine, calcium, magnesium vitamin B, vitamin E, omega-3 fatty acids, alpha lipoic acid and cannabinoids. It, however, makes sense to regulate other factors which are known to cause nerve injury such as alcohol intake and blood sugar levels.

When the sensation in hands and feet is affected one might be more prone to injury and sensible precautions are required like

• If the neuropathy involves your hands, protect them while using sharp objects, if it affects the feet protect them by wearing shoes even when you are indoors.
• Avoid extreme temperatures and keep your hands and feet covered, warm in cold weather
• Protect yourself from heat injuries especially when using warm water for washing bathing

What are the other causes of peripheral neuropathy?

There can be many other causes of peripheral nerve damage- some related to cancer and some independent. Determining the underlying cause is important as it may have a bearing on the treatment.

Related to cancer and its treatments.

• Surgery or radiotherapy
• Tumors pressing on nerves

Other independent causes

• Diabetes
• Alcohol abuse
• Shingles, infections involving the nerves
• Low vitamin B levels
• Spinal cord injuries
• Poor circulation (peripheral vascular disease)

How do we manage CIPN?

The importance of discussing with the admitting team, if symptoms of CIPN develop during treatment, has already been discussed. This provides an opportunity to modify treatment and prevent further damage rather than dealing with an irreversible situation later.

IF CIPN develops, pain can often be helped with treatments but the numbness is usually resistant to treatment. Some of the modalities which can be used for treatment include

• Medications used to treat nerve pain such as antiepileptics, antidepressants, topical gels, patches or creams of numbing medicine, strong painkillers such as opioids, steroids
• Drug infusions or pain relieving medications which act on nerves
• Physical therapy can help with balance, strength and safety.
• Occupational therapy can help improve fine motor skills like buttoning shirts
• Relaxation therapy, distraction, biofeedback

Some chemotherapy drugs which are likely to cause CIPN

Certain chemo drugs are more likely to cause CIPN. Some of the more common ones include:

• Platinum drugs like cisplatin, carboplatin, and oxaliplatin
• Taxanes including paclitaxel, docetaxel, and cabazitaxel
• Plant alkaloids such as vinblastine, vincristine, and etoposide
• Immunomodulating drugs like thalidomide, lenalidomide
• Proteasome inhibitors such as bortezomib, carfilzomib, and ixazomib

The post Are You suffering from numbness, tingling or burning sensation after Chemotherapy? appeared first on Dr Amod Blog.

One of the common presenting complaints of cancer is pain. Often pain is the reason behind a series of investigations culminating in the eventual diagnosis. Nearly 75% of pancreatic cancer patients suffer from pain at the time of diagnosis and these increases to over 90% in advanced stages.

The pain may be moderate to severe with adverse effect on quality of life, functional ability and mood. Most patients complain of intermittent or constant, deep pain in the upper part of tummy just below the ribcage. It may be squeezing, cramping, sharp, burning or aching in character. Pain is often more on the left and can spread towards the back. It is often aggravated by oral intake of fluids or solids.

Pain management in pancreatic cancer can be challenging because of the aggressive nature of the disease. There is evidence supporting earlier treatment of pain, so it’s better to seek help early.

Pain in cancer may be related to

• Cancer itself due to

• Increased pressure or the blockage of pancreatic ducts
• Inflammation of the pancreas /nearby areas

• Pressure/ spread to the neighbouring structures such as

• Nerves (in approximately 70–90% of cases)
• Blockage of the duodenum (the first part of the small intestine) impeding the flow of food
• Liver
• Bowel or peritoneum (inner covering of the tummy)
• Bone (not very common)

• Other associated problems such as constipation and digestion issues
• Distension of abdomen due to increased fluid (ascites)
• Irritation of diaphragm leading to the shoulder pain
• Side effect of treatments such as chemotherapy, radiotherapy, surgery (as in peripheral neuropathy (nerve damage) /enteritis)
• An unrelated coincidental problem such as arthritis of joints of the spine

What are Splanchnic nerves and Coeliac plexus?

Coeliac plexus is a network of nerves located in upper part of tummy (abdomen) just behind the pancreas. It lies deep in the tummy in front of spine and around a big blood vessel called aorta. This network of nerves plays an important role in sending messages from the upper abdominal organs to the brain.

Splanchnic nerves are a group of nerves located on both sides of the spine. They are closely related to the Coeliac ganglion and carry pain information from organs in your abdomen to the brain.

What kinds of procedures are performed to reduce pain in pancreatic cancer and how can they help?

The below mentioned procedures are utilised not only for pancreatic cancer but also for other upper abdominal cancers such as those of liver, gall bladder, stomach, some parts of intestine. These can also help in some non-cancer pains such as in chronic pancreatitis.

These procedures may not be a permanent cure for the pain but have the potential to offer significant & lasting relief. Nerve blocks work well for some people, but they don’t work for everyone and may take some time to show the full effects.

These procedures can be classified as

• Diagnostic blocks– Blocking the coeliac plexus of the splanchnic nerves involves injecting local anaesthetic with or without steroids around these nerves to interrupt the pain signals being sent to the brain. This can reduce the pain one perceives and help in predicting if other procedures such as neurolysis will work or not.
• Neurolytic blocks– these procedures involve use of chemicals such as alcohol / phenol to achieve prolonged interruption of pain signals being transmitted by nerves.
• Radiofrequency procedures for splanchnic nerves– these procedures utilise radiofrequency energy to heat the needle tip which in turn reduces the pain signals being transmitted to the brain.

Which intervention and approach is most suitable for a patient will depend on individual factors such as the extent of disease, concomitant problems such as breathing issues or ascites, ability to lie on the tummy/ back etc. Sometimes multidisciplinary review is required (such as reviewing the scans with radiologists) for deciding on the most suitable option.

Depending on the approach chosen the procedure may require for the patient to lie on their back or tummy for a period of approximately 45 min to an hour. A guiding modality is used to accurately place the needles close to the target nerves. This may include

• X Ray (Fluoroscopy) guidance
• Ultrasound guidance
• CT guidance
• Endoscopic guidance
• OR a combination of above mentioned modalities

Once the needles are in the correct place a dye may be used to assess how the medications would spread and to confirm the accurate placement of needles. An attempt is then made to reduce the pain signals being transmitted by these nerves via radiofrequency or drugs.

How much pain relief can be expected after the procedure and for how long will it last for?

The pain relief after the injection can vary depending on the cause of pain, location and extent of disease. In some studies, it has been observed that the outcomes are better if the block is performed soon after the onset of pain asin advanced disease large tumours can act as mechanical barrier preventing the spread of the drugs hence achieving only partial relief.

These procedures have the potential of reducing the pain and the medication requirement for medium term. Overall, 70%–80% of patients undergoing these procedures report decreased pain for 1–6 months.

What are the risks of having these procedures?

No intervention is risk free. The decision to perform or not perform an intervention is taken by evaluating the risk/benefit ratio. The risks will vary depending on the intervention chosen and the patient’s medical issues. When performing these procedures, precautions are taken to reduce the risks as much as possible such as performing the procedure under guidance (x-ray, ultrasound, CT etc), use of contrast (dye) to assess the spread of medications and use of electrical stimulation in radiofrequency procedures etc.

Common side effects of these procedures include local pain (96%), lowering of blood pressure (10%) and loose stools (44%). Fortunately most of the common side effects are short lasting.

Some of the risks can be serious. Studies have reported the risk of serious adverse events as approximately 2%. It is best to discuss these with your treating doctor as the list of these can be long and vary with the intervention chosen.

What else can be done to reduce the pain?

Painkillers Medications

Different types of pain killers can be used based on the type of pain and other medical problems. Often the painkillers dose needs to be changed or new ones need to be added as the disease changes.

Morphine and Morphine like drugs (collectively known as Opioids) are one of the strongest pain killers. Other drugs in this class include fentanyl and oxycodone. These painkillers can be given by different routes including orally, intravenously (directly into the veins), subcutaneously (below the skin) or as patches. Oral medications also come in a slow release form which provide more consistent pain relieve throughout the day. These drugs have often been in the limelight due to the wrong reasons such as addiction/ abuse potential and hence the social taboos associated with their use. Patients often do a disservice to themselves by harbouring preconceived notions and putting up barriers. It is important that you openly discuss any such issues with your Pain Specialist. 

Other types of pain may require different class of pain killers such as anti-inflammatories for pain due to inflammation, neuropathic medications such as gabapentin and pregabalin for nerve type of pain etc.

As with any other medication there are side effects associated with all these medications and these can be dealt with in most cases by patient education, pre-emptive action, use of medications and lifestyle modification.

Pain control in cancer is not just about medications or injections… there is more to it. To achieve a satisfactory control it often requires addressing the concomitant factors which can serve to enhance the pain experienced. For example

• Relationship between one’s emotional state such as low mood /anxiety and pain is well known. These factors can magnify the perceived pain and hence addressing them is important. Relaxation therapies such as meditation, mindfulness may help in managing thoughts, coping with feelings and produce a calming effect.
• Abdominal and back pain worsen with coexisting problems like constipation and abdominal distension and hence the importance of addressing these.

Refractory end of life pain can be dealt by delivering pain killers directly into the spine by using intrathecal/ epidural route.

The post Pancreatic Cancer Pain Management Coeliac Plexus & Splanchnic Nerve Blocks appeared first on Dr Amod Blog.